Critical analysis of radioiodination techniques for micro and macro organic molecules
作者： Sajid Mushtaq , Jongho Jeon , Aqeela Shaheen , Beom Su Jang , Sang Hyun Park
DOI: 10.1007/S10967-015-4679-Z
关键词: Chemistry 、 Organic molecules 、 Lipophilicity 、 Yield (chemistry) 、 Reaction conditions 、 Combinatorial chemistry 、 Organic compound 、 Organic chemistry 、 Macro 、 Regioselectivity 、 High specific activity
摘要: A variety of radioiodination methods is available in the literature depending upon nature organic compound to be labeled, however only few can completely fulfill manufacturing requirements.Ideally a selected method should one which offers maximum benefits like regioselectivity, minimum reaction steps, time, high radiochemical yield and specific activity. In this review techniques were critically analyzed. Advantages, drawbacks, possible mode action special conditions required get taken into account. The influence iodine introduction on physicochemical properties, vivo or vitro pharmacological properties pharmaceutical due increase lipophilicity discussed along with examples.
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