The contentious nature of gestational diabetes: diet, insulin, glyburide and metformin.

摘要: Gestational diabetes (GD) develops because pregnancy increases requirements for insulin secretion while increasing resistance. Women with GD often have impaired pancreatic β-cell compensation The nature of is currently contentious, debate about its existence, diagnosis and ramifications both mother offspring from into later life. Also contentious are the outcomes intervention diet, insulin, glyburide (Glynase™, Pharmacia Upjohn) metformin (Glucophage™, Bristol-Myers Squibb). There consensus that women unequivocal a significant risk adverse perinatal increased type 2 mellitus. Foetuses pregnancies higher macrosomia (associated rate birth injuries), asphyxia, neonatal hypoglycaemia hyperinsulinaemia. Uncontrolled predisposes foetuses to accelerated, excessive fat accumulation, resistance, exhaustion secondary ...