Osteonecrosis of the Jaw in Multiple Myeloma Patients: Clinical Features and Risk Factors

摘要: Purpose To describe the clinical, radiologic, and pathologic features risk factors for osteonecrosis of jaw (ONJ) in multiple myeloma (MM) patients. Patients Methods A retrospective review 90 MM patients who had dental assessments, including 22 with ONJ. There were 62 men; median age was 61 years ONJ 58 among rest. Prior therapy included thalidomide (n = 67) stem-cell transplantation 72). Bisphosphonate zoledronate 34) or pamidronate 17) followed by 33). Twenty-seven recent extraction, 12 group. Median time from diagnosis to 8.4 whole Results usually presented pain. occurred posterior cuspids 20) mostly mandible. Debridement sequestrectomy primary closure performed 14 patients; these, four major infections recu...