Neuroblastoma Cell Lines Contain Pluripotent Tumor Initiating Cells That Are Susceptible to a Targeted Oncolytic Virus
作者： Yonatan Y. Mahller , Jon P. Williams , William H. Baird , Bryan Mitton , Jonathan Grossheim
DOI: 10.1371/JOURNAL.PONE.0004235
关键词: Stem-cell therapy 、 Immunology 、 Cancer stem cell 、 Stem cell 、 Cellular differentiation 、 Cancer research 、 Biology 、 Neuroblastoma 、 Neural stem cell 、 Oncolytic virus 、 Progenitor cell 、 General Biochemistry, Genetics and Molecular Biology 、 General Agricultural and Biological Sciences 、 General Medicine
摘要: Background Although disease remission can frequently be achieved for patients with neuroblastoma, relapse is common. The cancer stem cell theory suggests that rare tumorigenic cells, resistant to conventional therapy, are responsible relapse. If true improved cure rates may only via identification and therapeutic targeting of the neuroblastoma tumor initiating cell. Based on cues from normal evidence populating progenitor cells has been found in a variety cancers.
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