Misreading of Ribonucleic Acid Code Words Induced by Aminoglycoside Antibiotics THE EFFECT OF DRUG CONCENTRATION

作者: J Davies , B D Davis

DOI: 10.1016/S0021-9258(18)93308-9

关键词: RNABiochemistryAminoglycosideParomomycinAntibioticsBiologyStreptomycinNeomycinGentamicinKanamycin

摘要: … antibiotics cause extensive misreading of the RNA code in vitro (1… tyrosine to isoleucine incorporation increased about 2-fold, whereas increasing concentrations of paromomycin did not …

参考文章(12)
Sidney Pestka, Studies on the Formation of Transfer Ribonucleic Acid-Ribosome Complexes Journal of Biological Chemistry. ,vol. 241, pp. 367- 372 ,(1966) , 10.1016/S0021-9258(18)96925-5
Joel G. Flaks, Edward C. Cox, James R. White, Inhibition of polypeptide synthesis by streptomycin Biochemical and Biophysical Research Communications. ,vol. 7, pp. 385- 389 ,(1962) , 10.1016/0006-291X(62)90320-0
Hideko Kaji, Yoriko Tanaka, Binding of dihydrostreptomycin to ribosomal subunits. Journal of Molecular Biology. ,vol. 32, pp. 221- 230 ,(1968) , 10.1016/0022-2836(68)90006-5
Shalom A. Leon, Thomas D. Brock, Effect of streptomycin and neomycin on physical properties of the ribosome Journal of Molecular Biology. ,vol. 24, pp. 391- 404 ,(1967) , 10.1016/0022-2836(67)90226-4
J. Davies, P. Anderson, B. D. Davis, Inhibition of Protein Synthesis by Spectinomycin Science. ,vol. 149, pp. 1096- 1098 ,(1965) , 10.1126/SCIENCE.149.3688.1096
L. Gorini, R. Rosset, R. A. Zimmermann, Phenotypic Masking and Streptomycin Dependence Science. ,vol. 157, pp. 1314- 1317 ,(1967) , 10.1126/SCIENCE.157.3794.1314
Bernard D. Davis, Porter Anderson, Julian Davies, Effect of spectinomycin on polypeptide synthesis in extracts of Escherichia coli Journal of Molecular Biology. ,vol. 29, pp. 203- 215 ,(1967) , 10.1016/0022-2836(67)90191-X
J. Davies, W. Gilbert, L. Gorini, STREPTOMYCIN, SUPPRESSION, AND THE CODE. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 51, pp. 883- 890 ,(1964) , 10.1073/PNAS.51.5.883