IL-6 functions as an exocrine hormone in inflammation. Hepatocytes undergoing acute phase responses require exogenous IL-6.

摘要: We have previously shown that IL-6 is the major monocyte- and fibroblast-derived regulator of acute phase protein gene expression synthesis in hepatocytes inflammation. Recently, we others rat human hepatoma cells express mRNA, question arose as to whether normal any such occurs under physiologic conditions or seen Poly A+ mRNA liver from rats undergoing an response was not positive when probed with cDNA for which macrophage strongly positive. then compared poly purified freshly isolated rats--from were inflammatory had been cultured 24 h presence absence dexamethasone (microM). Only glucocorticoid obviously IL-6. The increased gamma-fibrinogen indicated These results confirm identification exogenous hormone regulating hepatic inflammation rules out autocrine mechanism being active homeostasis.