Eicosanoids and Diabetic Hypertension

摘要: Hypertension is more common in juvenile onset diabetes than the normal population and considered to be a major risk factor this group of patients (Christlieb et al. 1981). More 2.5 million Americans suffer from associated with hypertension (Working Group on Diabetes 1987). The development vascular complications diabetes, namely diabetic macro- microangiopathy prothrombotic stage, eventually combined hypertension, might facilitated by general disturbance defence mechanisms body, being related insulin deficiency. This involves alterations eicosanoid production that are not only important for control secretion (Rosen Hohlfeld 1985; Robertson 1986) but also thrombotic disease. paper reviews present evidence contribution disturbed mellitus particular emphasis hypertension.