Publisher Correction to: Electrocardiogram-less, free-breathing myocardial extracellular volume fraction mapping in small animals at high heart rates using motion-resolved cardiovascular magnetic resonance multitasking: a feasibility study in a heart failure with preserved ejection fraction rat model.

摘要: BACKGROUND Extracellular volume fraction (ECV) quantification with cardiovascular magnetic resonance (CMR) T1 mapping is a powerful tool for the characterization of focal or diffuse myocardial fibrosis. However, it technically challenging to acquire high-quality and ECV maps in small animals preclinical research because high heart rates respiration rates. In this work, we developed an electrocardiogram (ECG)-less, free-breathing method using motion-resolved CMR Multitasking on 9.4 T animal system. The feasibility characterizing fibrosis was tested rat failure model preserved ejection (HFpEF). METHODS High-salt fed rats diagnosed HFpEF (n = 9) control were imaged proposed technique. A 25-min exam, including two 4-min scans before after gadolinium injection, performed each rat. It allows cardiac temporal resolution 20 ms rate of ~ 300 bpm. Myocardial calculated from hematocrit (HCT) fitted values myocardium blood pool. Masson's trichrome stain used measure extent Welch's t-test between groups. RESULTS significantly higher group (22.4% ± 2.5% vs. 18.0% ± 2.1%, P = 0.0010). moderate correlation found (R = 0.59, P = 0.0098). CONCLUSIONS Motion-resolved can quantify at without ECG triggering respiratory gating. Elevated consistent previous human studies well correlated histological data. This technique has potential be viable imaging tissue models.