Asymmetric expression of protein kinase CK2 subunits in human kidney tumors.

摘要: Abstract Renal clear cell carcinomas and the corresponding ipsilateral control tissues were investigated for protein kinase CK2 activity subunit ratio. The average from 21 different kidney samples was 318 U/mg that tumors 610 U/mg. ratio of CK2α in tumors/normal tissue (T/N) 1.58 CK2β 2.65. data suggest generally described increase tumor cells may to some extent result a deregulation biosynthesis or degradation. This at least partly owing presence excess enzymatically active α-subunit but also significantly higher non-catalytic β-subunit.