Chapter 29. Principles for multivalent ligand design

摘要: Publisher Summary This chapter focuses on principles for multivalent ligand design. Multivalent interactions control a wide variety of cellular processes including cell surface recognition events. Examples specific cell–cell binding events can be found in diverse processes, such as inflammation, tumor metastasis, and fertilization. An understanding the mechanistic that underlie facilitates generation new classes therapeutic agents biomaterials. Synthetic ligands used to illuminate exploit biological benefit from multipoint contacts. The use antibodies provide information about involvement particular process. Understanding structural requirements activity requires wider whose structure, size valency, controlled tailored. designing synthetic interplay between structure activity. overview three dimensional shape is presented flexibility Scaffold discussed. Incorporation ancillary functional groups elaborated design scaffolds also analyzed.