T-cell tolerance and the multi-functional role of IL-2R signaling in T-regulatory cells

摘要: Signaling through the interleukin-2 receptor (IL-2R) contributes to T-cell tolerance by controlling three important aspects of regulatory (Treg) biology. IL-2 is essential for thymic Treg development and regulates homeostasis suppressive function. Analogous activated conventional T lymphocytes, IL-2R signaling also plays an part in cell growth, survival, effector differentiation. However, cells somewhat distinctively assimilate signaling. In particular, require essentially only IL-2-dependent proximal signal transducer activator transcription 5 (Stat5) activation, as they contain inhibitory pathways minimize IL-2R-dependent activation phosphatidyinositol 3-kinase/Akt pathway. Moreover, many activities, including full induction Foxp3 expression, minimal transient Stat5 activation. Thus, are equipped sense then develop function within biological niches containing IL-2. These distinguishing features provide a mechanistic underpinning using agent selectively target immunotherapy induce autoimmune diseases allogeneic transplant recipients.