Ratio of reduced to oxidized glutathione as indicator of oxidative stress status and DNA damage

作者: Miguel Asensi , Juan Sastre , Federico V. Pallardo , Ana Lloret , Martin Lehner

DOI: 10.1016/S0076-6879(99)99026-2

关键词: High-performance liquid chromatographyAutoxidationChemistryGlutathioneDNA damageBiochemistryOxidative stress8-Hydroxy-2'-deoxyguanosineApoptosisGlutathione reductase

摘要: … Glutathione can be used to indicate oxidative stress. 1 In the past some attempts were made to correlate glutathione oxidation … For instance, Gohil et al. 14 tried to correlate glutathione …

参考文章(15)
J Viña, R Hems, H A Krebs, Maintenance of glutathione content is isolated hepatocyctes Biochemical Journal. ,vol. 170, pp. 627- 630 ,(1978) , 10.1042/BJ1700627
José Garcia De La Asuncion, Arantxa Millan, Rosa Pla, Leo Bruseghini, Antonio Esteras, Federico V. Pallardo, Juan Sastre, José Viña, Mitochondrial glutathione oxidation correlates with age-associated oxidative damage to mitochondrial DNA. The FASEB Journal. ,vol. 10, pp. 333- 338 ,(1996) , 10.1096/FASEBJ.10.2.8641567
Nechama S. Kosower, Edward M. Kosower, The Glutathione Status of Cells International Review of Cytology-a Survey of Cell Biology. ,vol. 54, pp. 109- 160 ,(1978) , 10.1016/S0074-7696(08)60166-7
D.J. Reed, J.R. Babson, P.W. Beatty, A.E. Brodie, W.W. Ellis, D.W. Potter, High-performance liquid chromatography analysis of nanomole levels of glutathione, glutathione disulfide, and related thiols and disulfides. Analytical Biochemistry. ,vol. 106, pp. 55- 62 ,(1980) , 10.1016/0003-2697(80)90118-9
Regina Brigelius, Christian Muckel, Theodorus P.M. Akerboom, Helmut Sies, Identification and quantitation of glutathione in hepatic protein mixed disulfides and its relationship to glutathione disulfide Biochemical Pharmacology. ,vol. 32, pp. 2529- 2534 ,(1983) , 10.1016/0006-2952(83)90014-X
M. Asensi, J. Sastre, F.V. Pallardo, J.G. Delaasuncion, J.M. Estrela, J. Vina, A High-Performance Liquid Chromatography Method for Measurement of Oxidized Glutathione in Biological Samples Analytical Biochemistry. ,vol. 217, pp. 323- 328 ,(1994) , 10.1006/ABIO.1994.1126
Ernest Beutler, Satish K. Srivastava, Carol West, The reversibility of N-ethylmaleimide (NEM) alkylation of red cell glutathione Biochemical and Biophysical Research Communications. ,vol. 38, pp. 341- 347 ,(1970) , 10.1016/0006-291X(70)90718-7