Cytoskeletal Control of B Cell Responses to Antigens
作者： Pavel Tolar
DOI: 10.1038/NRI.2017.67
关键词: Arp2/3 complex 、 Actin cytoskeleton 、 B-cell receptor 、 Cytoskeleton 、 Biology 、 breakpoint cluster region 、 Cell signaling 、 B cell 、 Cell biology 、 Actin
摘要: The actin cytoskeleton is essential for cell mechanics and has increasingly been implicated in the regulation of signalling. In B cells, extensively coupled to receptor (BCR) signalling pathways, defects can either promote or suppress activation. Recent insights from studies using single-cell imaging biophysical techniques suggest that orchestrates BCR at plasma membrane through effects on protein diffusion it regulates antigen discrimination biomechanics immune synapses. These mechanical functions also have a role adaptation subsets specialized tasks during antibody responses.
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