ORIGINAL RESEARCH—WOMEN'S SEXUAL HEALTH: An Effect on the Subjective Sexual Response in Premenopausal Women with Sexual Arousal Disorder by Bremelanotide (PT‐141), a Melanocortin Receptor Agonist

摘要: ABSTRACT Introduction Melanocortins affect multiple physiological responses, including sexual behaviors. Bremelanotide is a synthetic peptide melanocortin analog of α‐melanocyte‐stimulating hormone that an agonist at receptors MC3R and MC4R. Aim To evaluate single intranasal dose bremelanotide for potential effects on subjective measurements arousal desire in premenopausal women with disorder. Main Outcome Measures Change vaginal pulse amplitude during neutral erotic videos after treatment or placebo subjects’ perceptions response within 24 hours placebo. Methods Eighteen primary diagnosis female disorder were randomly assigned to receive 20 mg matching double‐blind manner the first in‐clinic session, alternate medication second session. During each subjects viewed 20‐minute video followed by sexually explicit video. Vaginal photoplethysmography was used monitor vasocongestion questionnaires following 24‐hour period. Results More reported moderate high vs. ( P  = 0.0114), trend toward more positive responses regarding feelings genital occurred compared 0.0833). Among who attempted intercourse treatment, significantly satisfied their level bremelanotide, 0.0256). did not change while viewing administration Conclusion This preliminary evaluation suggests positively indicates promising candidate further at‐home study. Diamond LE, Earle DC, Heiman JR, Rosen RC, Perelman MA, Harning R. An effect (PT‐141), receptor agonist. J Sex Med 2006;3:628–638.