Posttranslational cleavage of cell‐surface receptors
作者： Martin Stacey , John Davies , Siamon Gordon , Hsi-Hsien Lin
DOI: 10.1002/047001153X.G305318
关键词: Proteolysis 、 Cell surface receptor 、 Posttranslational modification 、 Biochemistry 、 Cleavage (embryo) 、 Receptor 、 Biology 、 Cell biology
摘要: Nascent polypeptides generated by eukaryotes rarely represent the true form of mature proteins. Instead, many newly synthesized proteins undergo posttranslational modifications that may mediate either subtle or profound effects on function protein. In this review, we focus proteolytic cleavage as a type irreversible modification. We describe different mechanisms three disparate families cell-surface receptors; Notch receptors, protease-activated receptors (PARs) and G-protein receptor site (GPS) containing receptors. All these exemplify how modification proteolysis can greatly affect through variety intriguing mechanisms. Keywords: proteolytic; receptor cleavage; Notch; GPS; PAR; posttranslational
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