Thalidomide, Cyclooxygenase-2, and Angiogenesis: Potential for Therapy

作者: Roy S. Herbst , Jennifer E. Tseng , Amir Onn

DOI:

关键词: AngiogenesisThalidomidePharmacologyMedicineCyclooxygenase

摘要: Very few drugs in modern history have had a similar to that of thalidomide. First introduced the late 1950s Germany [(1)][1] , thalidomide soon became available total 46 countries, including Canada and United Kingdom but not States. Originally, it was marketed as

参考文章(24)
Isaiah J. Fidler, Lee M. Ellis, Chemotherapeutic drugs—more really is not better Nature Medicine. ,vol. 6, pp. 500- 502 ,(2000) , 10.1038/74969
Isaiah J. Fidler, Angiogenesis and cancer metastasis. Cancer Journal. ,vol. 6, pp. 20- ,(2000)
Barbara F. Hales, Thalidomide on the comeback trail. Nature Medicine. ,vol. 5, pp. 489- 490 ,(1999) , 10.1038/8371
Peter Carmeliet, Rakesh K. Jain, Angiogenesis in cancer and other diseases Nature. ,vol. 407, pp. 249- 257 ,(2000) , 10.1038/35025220
Renata Pasqualini, Donald M. McDonald, Wadih Arap, Vascular targeting and antigen presentation Nature Immunology. ,vol. 2, pp. 567- 568 ,(2001) , 10.1038/89704
DuBois Rn, Morrow Jd, Beauchamp Rd, Shao J, Sheng H, Modulation of Apoptosis and Bcl-2 Expression by Prostaglandin E2 in Human Colon Cancer Cells Cancer Research. ,vol. 58, pp. 362- 366 ,(1998)
Fadlo R. Khuri, Reuben Lotan, Bonnie L. Kemp, Lei Feng, Xiao-Chun Xu, Scott M. Lippman, J. Jack Lee, Waun K. Hong, Hong Wu, Cyclooxygenase-2 overexpression is a marker of poor prognosis in stage I non-small cell lung cancer. Clinical Cancer Research. ,vol. 7, pp. 861- 867 ,(2001)
Said M. Baidas, Eric P. Winer, Gini F. Fleming, Lyndsay Harris, James M. Pluda, Jeanette G. Crawford, Hideko Yamauchi, Claudine Isaacs, John Hanfelt, Mariella Tefft, David Flockhart, Michael D. Johnson, Michael J. Hawkins, Marc E. Lippman, Daniel F. Hayes, Phase II Evaluation of Thalidomide in Patients With Metastatic Breast Cancer Journal of Clinical Oncology. ,vol. 18, pp. 2710- 2717 ,(2000) , 10.1200/JCO.2000.18.14.2710
Richard F. Little, Kathleen M. Wyvill, James M. Pluda, Lauri Welles, Vickie Marshall, William D. Figg, Fonda M. Newcomb, Giovanna Tosato, Ellen Feigal, Seth M. Steinberg, Denise Whitby, James J. Goedert, Robert Yarchoan, Activity of Thalidomide in AIDS-Related Kaposi’s Sarcoma Journal of Clinical Oncology. ,vol. 18, pp. 2593- 2602 ,(2000) , 10.1200/JCO.2000.18.13.2593
R. J. D'Amato, M. S. Loughnan, E. Flynn, J. Folkman, Thalidomide is an inhibitor of angiogenesis. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 91, pp. 4082- 4085 ,(1994) , 10.1073/PNAS.91.9.4082