From neurons to neuron neighborhoods: The rewiring of the cerebellar cortex in essential tremor

摘要: Remarkably little has been written on the biology of essential tremor (ET), despite its high prevalence. The olivary model, first proposed in 1970s, is traditional disease model for ET; however, problematic a number reasons. Recently, intensive tissue-based studies have identified series structural changes brains most ET cases, and nearly all observed are located cerebellar cortex. These suggest that Purkinje cells central to pathogenesis may thus provide focus development novel therapeutic strategies. Arising from these studies, new proposes population represents site initial molecular/cellular events leading ET. Furthermore, secondary changes/remodeling molecular granular layers (i.e., cell “neighborhood”) likely be additional mechanistic importance. On physiological level, presence remodeling indicates formation aberrant synapses creation new/abnormal cortical circuits Specific efforts need devoted understanding cascade biochemical cellular occurring layer neuron neighborhood, as well effects remodeling/rewiring this brain region