Relationship Between Testosterone Levels, Insulin Sensitivity, and Mitochondrial Function in Men

摘要: OBJECTIVE — The goal of this study was to examine the relationship between serum testosterone levels and insulin sensitivity mitochondrial function in men. RESEARCH DESIGN AND METHODS —A total 60 men (mean age 60.5 ± 1.2 years) had a detailed hormonal metabolic evaluation. Insulin measured using hyperinsulinemic-euglycemic clamp. Mitochondrial assessed by measuring maximal aerobic capacity ( V o 2max ) expression oxidative phosphorylation genes skeletal muscle. RESULTS 45% subjects normal glucose tolerance, 20% impaired 35% type 2 diabetes. Testosterone were positively correlated with r = 0.4, P n 10) BMI >25 kg/m threefold higher prevalence syndrome than their eugonadal counterparts 50); held true after adjusting for sex hormone–binding globulin but not BMI. also 0.43, 0.57, CONCLUSIONS —These data indicate that low are associated an adverse profile suggest novel unifying mechanism previously independent observations promote resistance