Precision Dosing in Children

摘要: ABSTRACTUnlike adult medicine, there are fewer choices of medicines per condition in children, and for existing medications, supporting data on pharmacokinetics, pharmacodynamics, or pharmacogenomics is often incomplete. Many pediatric doses calculated using body weight to produce a dose the individual child, but this not true personalisation as suggested (usually mg/kg) same large age range children. The challenge implementation precision medicine pediatrics therefore develop an appropriate evidence base (particularly unlicensed off label medications), then add onto it relevant genotype, environmental lifestyle guide both medication selection (where exist) required. This review will consider where consideration crucial pediatrics, including developmental changes across childhood, obesity, old new dosing scarce and/or inadequately extrapolated ...