Leukocyte Mitochondrial DNA Copy Number in Blood Is Not Associated with Major Depressive Disorder in Young Adults

摘要: Background Major depressive disorder (MDD) is the leading cause of disability worldwide, and has significant genetic predisposition. Mitochondria may have a role in MDD so mitochondrial DNA (mtDNA) been suggested as possible biomarker for this disease. We aimed to test whether mtDNA copy number peripheral blood leukocytes related young adults. Methods A case-control study was conducted with 210 patients 217 healthy controls (HC). The measured by quantitative polymerase chain reaction (qPCR) method. Depression severity assessed Hamilton-17 Rating Scale (HDRS-17). Results We found no differences between HC, though power analysis showed that our sample size enough detect difference. There were also correlations clinical characteristics (such age, age onset, episodes, Hamilton (HDRS) score Global Assessment Function (GAF) score) patients. Conclusion Our suggests leukocyte unlikely contribute MDD, but it doesn’t mean we can exclude possibility involvement mitochondria Further studies are required elucidate be MDD.