Interaction of Prenatal Exposure to Cigarettes and MAOA Genotype in Pathways to Youth Antisocial Behavior
作者： R J Wright , E H Cook , L S Wakschlag , E O Kistner , D S Pine
DOI: 10.1038/MP.2009.22
关键词: Genetic predisposition 、 Cohort 、 Monoamine oxidase A 、 Genotype 、 Psychology 、 Conduct disorder 、 Variable number tandem repeat 、 Attribution bias 、 Pregnancy 、 Genetics
摘要: Genetic susceptibility to antisocial behavior may increase fetal sensitivity prenatal exposure cigarette smoke. Testing putative gene × mechanisms requires precise measurement of and outcomes. We tested whether a functional polymorphism in the encoding enzyme monoamine oxidase A (MAOA) interacts with predict pathways adolescent behavior. assessed both clinical information-processing One hundred seventy-six adolescents their mothers participated follow-up pregnancy cohort well-characterized exposure. sex-specific pattern interaction was detected. Exposed boys low-activity MAOA 5′ uVNTR (untranslated region variable number tandem repeats) genotype were at increased risk for conduct disorder (CD) symptoms. In contrast, exposed girls high-activity CD symptoms hostile attribution bias on face-processing task. There no evidence gene–environment correlation (rGE). Findings suggest that genotype, cigarettes sex interact related patterns. Future research replicate extend these findings should focus elucidating how interactions shape through associated changes brain function.
nature.com
sci-hub.se 参考文章(69)
Mary K. Wojczynski, Hemant K. Tiwari, Definition of phenotype. Advances in Genetics. ,vol. 60, pp. 75- 105 ,(2008) , 10.1016/S0065-2660(07)00404-X
Cathy Spatz Widom, Linda M. Brzustowicz, MAOA and the "cycle of violence:" childhood abuse and neglect, MAOA genotype, and risk for violent and antisocial behavior. Biological Psychiatry. ,vol. 60, pp. 684- 689 ,(2006) , 10.1016/J.BIOPSYCH.2006.03.039
Theodore A Slotkin, Emiko A MacKillop, Charles L Rudder, Ian T Ryde, Charlotte A Tate, Frederic J Seidler, Permanent, Sex-Selective Effects of Prenatal or Adolescent Nicotine Exposure, Separately or Sequentially, in Rat Brain Regions: Indices of Cholinergic and Serotonergic Synaptic Function, Cell Signaling, and Neural Cell Number and Size at 6 Months of Age Neuropsychopharmacology. ,vol. 32, pp. 1082- 1097 ,(2007) , 10.1038/SJ.NPP.1301231
Lauren S. Wakschlag, Bennett L. Leventhal, Daniel S. Pine, Kate E. Pickett, Alice S. Carter, Elucidating Early Mechanisms of Developmental Psychopathology: The Case of Prenatal Smoking and Disruptive Behavior. Child Development. ,vol. 77, pp. 893- 906 ,(2006) , 10.1111/J.1467-8624.2006.00909.X
Roberto Toro, Gabriel Leonard, Jacqueline V Lerner, Richard M Lerner, Michel Perron, G Bruce Pike, Louis Richer, Suzanne Veillette, Zdenka Pausova, Tomáš Paus, None, Prenatal Exposure to Maternal Cigarette Smoking and the Adolescent Cerebral Cortex Neuropsychopharmacology. ,vol. 33, pp. 1019- 1027 ,(2008) , 10.1038/SJ.NPP.1301484
R.J.R. Blair, The roles of orbital frontal cortex in the modulation of antisocial behavior Brain and Cognition. ,vol. 55, pp. 198- 208 ,(2004) , 10.1016/S0278-2626(03)00276-8
Rosalind J. Neuman, Elizabeth Lobos, Wendy Reich, Cynthia A. Henderson, Ling-Wei Sun, Richard D. Todd, Prenatal smoking exposure and dopaminergic genotypes interact to cause a severe ADHD subtype. Biological Psychiatry. ,vol. 61, pp. 1320- 1328 ,(2007) , 10.1016/J.BIOPSYCH.2006.08.049
John P. Hanrahan, Ira B. Tager, Mark R. Segal, Tor D. Tosteson, Robert G. Castile, Helen Van Vunakis, Scott T. Weiss, Frank E. Speizer, The Effect of Maternal Smoking during Pregnancy on Early Infant Lung Function American Review of Respiratory Disease. ,vol. 145, pp. 1129- 1135 ,(1992) , 10.1164/AJRCCM/145.5.1129
MONIQUE ERNST, ERIC T. MOOLCHAN, MIQUN L. ROBINSON, Behavioral and neural consequences of prenatal exposure to nicotine. Journal of the American Academy of Child and Adolescent Psychiatry. ,vol. 40, pp. 630- 641 ,(2001) , 10.1097/00004583-200106000-00007
F Ducci, M-A Enoch, C Hodgkinson, K Xu, M Catena, R W Robin, D Goldman, Interaction between a functional MAOA locus and childhood sexual abuse predicts alcoholism and antisocial personality disorder in adult women. Molecular Psychiatry. ,vol. 13, pp. 334- 347 ,(2008) , 10.1038/SJ.MP.4002034