Early changes in myocardial antioxidant enzymes in rats treated with adriamycin

摘要: Increased oxidative stress and antioxidant deficit have been suggested to play a major role in adriamycin-induced cardiomyopathy congestive heart failure due multiple treatments with adriamycin (doxorubicin). In this study, we investigated the acute effects of single dose on myocardial enzymes rats. Adriamycin (2.5 mg/kg) was injected (i.p.) enzyme activities, mRNA abundance protein levels at 1, 2, 4 24 h were examined. While manganese superoxide dismutase (MnSOD), glutathione peroxidase (GSHPx) catalase (CAT) activities not significantly changed, copper-zinc (CuZnSOD) activity reduced all time points change correlated decrease its content. CuZnSOD increased 1 h. GSHPx transiently decreased by 20 25% respectively 2 MnSOD but Lipid peroxidation A transient depression as well increase may precede more sustained changes seen repeated administration drug contribute development failure.