Disrupted Working Memory Circuitry in Adolescent Psychosis.

摘要: Individuals with schizophrenia (SZ) consistently show deficits in spatial working memory (WM) and associated atypical patterns of neural activity within key WM regions, including the dorsolateral prefrontal cortex (dlPFC) parietal cortices. However, little research has focused on adolescent psychosis (AP) potential age-associated disruptions circuitry that may occur youth this severe form illness. Here we utilized each subject's individual capacity to investigate task-based dysfunction 17 patients AP (16.58 ± 2.60 years old) as compared typically developing, demographically comparable adolescents (18.07 3.26 old). showed lower behavioral performance at higher loads overall healthy controls. Whole-brain activation analyses revealed greater bilateral precentral right postcentral controls relative patients, when controlling for capacity. Seed-based psychophysiological interaction (PPI) significantly co-activation between left dlPFC frontal pole patients. Significant group-by-age interactions were observed both whole-brain PPI analyses, showing atypically stronger coupling task activated brain regions a function increasing age. Additionally, demonstrated positive relationships performance, but unlike controls, failed associations out-of-scanner neurocognitive performance. Collectively, these findings are consistent WM-related functioning disrupted developmental processes AP.