Hybrid LC-MS as a powerful tool for supporting protein bioanalysis in gene and cell therapies.

Jonathan D. Jones, B. JoNell Hamilton, William F. C. Rigby, Rituximab mediates loss of CD19 on B cells in the absence of cell death Arthritis & Rheumatism. ,vol. 64, pp. 3111- 3118 ,(2012) , 10.1002/ART.34560

Amit C. Nathwani, John T. Gray, Jenny McIntosh, Catherine Y. C. Ng, Junfang Zhou, Yunyu Spence, Melanie Cochrane, Elaine Gray, Edward G. D. Tuddenham, Andrew M. Davidoff, Safe and efficient transduction of the liver after peripheral vein infusion of self-complementary AAV vector results in stable therapeutic expression of human FIX in nonhuman primates Blood. ,vol. 109, pp. 1414- 1421 ,(2007) , 10.1182/BLOOD-2006-03-010181

Michael Kalos, Biomarkers in T cell therapy clinical trials. Journal of Translational Medicine. ,vol. 9, pp. 138- 138 ,(2011) , 10.1186/1479-5876-9-138

Thomas McAvoy, Michael E Lassman, Daniel S Spellman, Zhenlian Ke, Bonnie J Howell, Oitak Wong, Lan Zhu, Michael Tanen, Arie Struyk, Omar F Laterza, Quantification of Tau in Cerebrospinal Fluid by Immunoaffinity Enrichment and Tandem Mass Spectrometry Clinical Chemistry. ,vol. 60, pp. 683- 689 ,(2014) , 10.1373/CLINCHEM.2013.216515

Elena Sotillo, David M. Barrett, Kathryn L. Black, Asen Bagashev, Derek Oldridge, Glendon Wu, Robyn Sussman, Claudia Lanauze, Marco Ruella, Matthew R. Gazzara, Nicole M. Martinez, Colleen T. Harrington, Elaine Y. Chung, Jessica Perazzelli, Ted J. Hofmann, Shannon L. Maude, Pichai Raman, Alejandro Barrera, Saar Gill, Simon F. Lacey, Jan J. Melenhorst, David Allman, Elad Jacoby, Terry Fry, Crystal Mackall, Yoseph Barash, Kristen W. Lynch, John M. Maris, Stephan A. Grupp, Andrei Thomas-Tikhonenko, Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy Cancer Discovery. ,vol. 5, pp. 1282- 1295 ,(2015) , 10.1158/2159-8290.CD-15-1020

Gregory Lizée, Joeri L. Aerts, Monica I. Gonzales, Nachimuthu Chinnasamy, Richard A. Morgan, Suzanne L. Topalian, Real-time quantitative reverse transcriptase-polymerase chain reaction as a method for determining lentiviral vector titers and measuring transgene expression Human Gene Therapy. ,vol. 14, pp. 497- 507 ,(2003) , 10.1089/104303403764539387

Xavier M. Anguela, Katherine A. High, Entering the Modern Era of Gene Therapy. Annual Review of Medicine. ,vol. 70, pp. 273- 288 ,(2019) , 10.1146/ANNUREV-MED-012017-043332

Savita Rangarajan, Liron Walsh, Will Lester, David Perry, Bella Madan, Michael Laffan, Hua Yu, Christian Vettermann, Glenn F. Pierce, Wing Y. Wong, K. John Pasi, AAV5–Factor VIII Gene Transfer in Severe Hemophilia A The New England Journal of Medicine. ,vol. 377, pp. 2519- 2530 ,(2017) , 10.1056/NEJMOA1708483

ZeNan L Chang, Michael H Lorenzini, Ximin Chen, Uyen Tran, Nathanael J Bangayan, Yvonne Y Chen, Rewiring T-cell responses to soluble factors with chimeric antigen receptors. Nature Chemical Biology. ,vol. 14, pp. 317- 324 ,(2018) , 10.1038/NCHEMBIO.2565

Yue Zhao, Huidong Gu, Jianing Zeng, Opportunities and challenges for hybrid immunoaffinity LC-MS approach for quantitative analysis of protein biomarkers. Future Science OA. ,vol. 4, ,(2018) , 10.4155/FSOA-2017-0148