Experimental induction of hepatic lipidosis in cats.

摘要: The effect of long-term voluntary fasting on hematologic variables, biochemical profiles, and liver histologic findings was assessed in 15 obese cats (> 40% overweight). Clinical signs laboratory results consistent with hepatic lipidosis were observed 12 after 5 to 7 weeks fasting, associated 30 35% reduction initial body weight. Histologic examination successive biopsy specimens revealed that obesity not parenchymal lipid accumulation, but resulted all cats. fast an early (after 2 4 fasting) significant (P < 0.05) serum urea, glucose, albumin concentrations, RBC mass. Fasting for a increase hepatic-associated enzyme activities total direct bilirubin concentrations. Significant changes alkaline phosphatase developed as 3 before the onset hyperbilirubinemia. Except development lipidosis, appeared tolerate without other adverse effect. This study confirmed may induce clinical appears syndrome is indistinguishable from feline idiopathic be appropriate model pathophysiologic features treatment lipidosis.