GLP-1 as a satiety factor in children with eating disorders.

摘要: GLP-1, with its insulinotropic properties and direct action on satiety center in the brain, may be main hormone regulating amount of ingested food. In this study, GLP-1 secretion was investigated age-matched adolescent girls (14 +/- 2 years): 13 anorexia nervosa (BMI 14.8 1.4 kg/m(2)), simple obesity 33.0 3.3 kg/m(2)) 10 healthy as a control group 21.6 0.7 kg/m(2)). Each girl subjected to OGTT standard meal tests after 12 h overnight fast. Blood samples were collected before 15, 30, 60, 120 min stimulation. The mean fasted levels (1.6 0.3 pmol/l) (1.7 significantly lower than those (2.6 0.4 (p < 0.05 both cases). highest peak concentration observed stimuli. each group, integrated outputs almost twice high test 0.001 case). our opinion, low seriously negatively influence course disease. On other hand, are beneficial promote appetite.