Do we need to explain the occurrence of atypical scrapie?

摘要: WHY do diseases occur? A recent paper by Tomasetti and colleagues (2017) tries to provide new evidence in support of their hypothesis that most cancers may be accounted for mutations due unpredictable, random mistakes made during normal DNA replication the division stem cells (somatic mutations) (Tomasetti Vogelstein 2015). They suggest other arise environmental or heredity factors only play a minor role. The debate on this issue is still open while media translated into concept ‘bad luck’. As highlighted Centers Disease Control Prevention (CDC) reference manual, ‘epidemiologists assume illness does not occur randomly population, but happens when right accumulation risk determinants exists an individual’ (CDC 2011). same assumption should also hold applied transmissible spongiform encephalopathies (TSEs), whose origin causes are obvious. That case sporadic Creutzfeldt Jakob disease (CJD) humans livestock TSEs than classical bovine encephalopathy (BSE) scrapie. Let's take step back. During 1990s, at peak BSE epidemic UK, possibility might have spread small ruminant population led renewed attention surveillance Although scrapie had been known since 18th century, real distribution was clear. Therefore, throughout Europe, passive targeting sheep …