Primary Central Nervous System Lymphoma: Overview of Current Treatment Strategies

摘要: Primary central nervous system lymphoma (PCNSL) is an uncommon and aggressive variant of non-Hodgkin that involves the brain, eyes, leptomeninges, or spinal cord. Therapeutic progress has been modest, our understanding molecular mechanisms drive this disease limited. Clinicians treating PCNSL face a challenge to balance need administer regimens achieve cure with risks delayed neurotoxicity after treatment. The standard treatment methotrexate-containing chemotherapy regimen. timing dose whole-brain radiation therapy controversial, given significant late neurotoxic effects, particularly in elderly patients.