Natural and engineered kallikrein inhibitors: an emerging pharmacopoeia
作者： Joakim E. Swedberg , Simon J. de Veer , Jonathan M. Harris
DOI: 10.1515/BC.2010.037
关键词: Semen liquefaction 、 Kallikrein 、 Proteases 、 Biochemistry 、 SKIN DESQUAMATION 、 Biology 、 Pharmacopoeia 、 Computational biology 、 Kallikrein inhibitor
摘要: The kallikreins and kallikrein-related peptidases are serine proteases that control a plethora of developmental homeostatic phenomena, ranging from semen liquefaction to skin desquamation blood pressure. diversity roles played by has stimulated considerable interest in these enzymes the perspective diagnostics drug design. Kallikreins already have well-established credentials as targets for therapeutic intervention there is increasing appreciation their potential both biomarkers inhibitor Here, we explore current status naturally occurring kallikrein protease-inhibitor complexes illustrate how this knowledge can interface with strategies rational re-engineering bioscaffolds design small-molecule inhibitors.
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