Weight-reducing effects of the plasma protein encoded by the obese gene.

摘要: The gene product of the ob locus is important in regulation body weight. was shown to be present as a 16-kilodalton protein mouse and human plasma but undetectable from C57BL/6J ob/ob mice. Plasma levels this were increased diabetic (db) mice, mutant thought resistant effects ob. Daily intraperitoneal injections either or recombinant OB reduced weight mice by 30 percent after 2 weeks treatment with no apparent toxicity had effect on db/db food intake energy expenditure Injections wild-type twice daily resulted sustained 12 loss, decreased intake, reduction fat 12.2 0.7 percent. These data suggest that serves an endocrine function regulate stores.