CHAPTER 10 – Interleukin-4

摘要: This chapter focuses on interleukin (IL)-4, which is produced by and affects many cell types. The biological milieu provides signals for the production of IL-4, at same time, effects IL-4 depend timing maturation/activation stage influences differentiation effector cells level antigen presentation, activation T cells. presence other cytokines can also dramatically change outcome an immune response. For cancer patients, local delivery gene vectors may hold more promise than recombinant achieving high concentration cytokine site induction anti-tumor Development effective regulatable systems allow to design combination strategies multiple based a deeper understanding how each plays role in sequence events. Understanding receptors their expression has led development toxin-conjugated treatment cancer. Soluble forms receptor be important patients with allergic diseases. In diseases excess HI shifted balance apparent, such as chronic inflammatory diseases, rIL-4 or therapeutic benefit. signal transduction, messenger molecules well structure IL-4R, complexes specific inhibitors enhancers complex biologic properties IL-4.