Hydrazine containing conjugates of polypeptides and glycopolypeptides with polymers
作者： Chyi Lee , Sunitha Menon-Rudolph , Samuel Zalipsky
DOI:
关键词: Moiety 、 Amino acid 、 Functional group 、 Hydrazone 、 Peptide 、 Hydrazide 、 Chemistry 、 Carboxylic acid 、 Peptide sequence 、 Stereochemistry
摘要: Biologically active macromolecular conjugates of a biologically polypeptide or glycopolypeptide and one more water-soluble polymer molecules covalently bonded thereto at reactive carbonyl carboxylic acid group peptide moiety on the an oxidized carbohydrate by linkage containing hydrazide hydrazone functional group. The preferably also includes amino sequence.
google.com.mx参考文章(8)
Walter J. Laird, Lois Aldwin, Danute E. Nitecki, Paula J. Shadle, Margaret Moreland, John D. Young, Nandini Katre, Kirston E. Koths, Conjugation of polymer to colony stimulating factor-1 ,(1989)
Michael James Knauf, Nandini Katre, Solubilization of proteins for pharmaceutical compositions using polymer conjugation ,(1986)
Shmuel Zalipsky, Active carbonates of polyalkylene oxides for modification of polypeptides ,(1990)
Kuno Dr. Wagner, Peter Dr. Roessler, Helmut Dr. Tietz, Edgar Dr. Möhring, Hanns Peter Dr. Müller, Method of improving the solubility of biologically active agents in water and in lower aliphatic alcohols, and compounds having an improved solubility ,(1979)
Nobuyuki YAMASAKI, Akira MATSUO, Hiroshi ISOBE, Novel Polyethylene Glycol Derivatives for Modification of Proteins Agricultural and biological chemistry. ,vol. 52, pp. 2125- 2127 ,(1988) , 10.1271/BBB1961.52.2125
Talia Miron, Meir Prof Wilchek, Immobilized protein preparations - in which proteins are bound to polymeric carriers via hydrazine residues ,(1975)
Toshiyuki Nagai, Kanji Fujita, Shigeyoshi Fukushima, Novel process for immobilization of enzyme ,(1977)
Alan J. Johnson, Anne J. Fulton, Modified factor VIII ,(1989)