Biological, mechanical, and technological considerations affecting the longevity of intracortical electrode recordings.

摘要: Intracortical electrodes are important tools, with applications ranging from fundamental laboratory studies to potential solutions intractable clinical applications. However, the longevity and reliability of interfaces remain their major limitation wider implementation adoption this technology, especially in broader translational work. Accordingly, review summarizes most significant biological technical factors influencing long-term performance intracortical electrodes. In a setting, have been used study normal abnormal function brain. This improved understanding has led valuable insights regarding many neurological conditions. Likewise, brain-machine offer ability improve quality life patients afflicted high-level paralysis spinal cord injury, brain stem stroke, amyotrophic lateral sclerosis, or other It is widely hypothesized that tissue response electrodes, including inflammation, limits longevity. Many examined modified future electrode technologies. Overall, relationship between biological, mechanical, technological considerations crucial for fidelity chronic recordings represent presently active area investigation field neural engineering.