Is there nicotinic modulation of nerve growth factor? Implications for cholinergic therapies in Alzheimer’s disease

摘要: Studies on the neurobiology of nerve growth factor (NGF) reveal a diverse range actions. Through alterations in gene expression, NGF is important maintaining and regulating phenotype neurons that express high-affinity receptor, trkA. Nerve also has rapid action, revealed by its role pain signaling bladder skin. In central nervous system (CNS), an intimate relationship with cholinergic system. It promotes neuron survival after experimental injury but maintains regulates uninjured neurons. addition to these effects mediated neurotransmitter-like action regulate neurotransmission neuronal excitability. Consistent actions system, can enhance function animals lesions been proposed be useful humans Alzheimer's disease (AD); however, problems CNS delivery side (particularly pain) limit clinical efficacy NGF. Drug treatment strategies production may AD. Nicotine one such agent, which, when administered directly hippocampus rats, produces long-lasting elevation production.