Culture-Negative Prosthetic Joint Infection

摘要: Background. Culture-negative (CN) prosthetic joint infection (PJI) has not been well studied. We performed a retrospective cohort study to define the demographic characteristics and determine outcome of patients with CN PJI. Methods. All cases total hip arthroplasty knee infections (using strict case definition) treated at our institution from January 1990 through December 1999 were analyzed. Kaplan-Meier survival methods used cumulative probability success. Results. Of 897 episodes PJI during period, 60 (7%) occurred in for whom this was initial episode The median age 69 years (range, 36‐87 years). Patients had received prior course antimicrobial therapy 32 (53%) episodes. episodes, 34 (57%), 12 (20%), 8 (13%) 2-stage exchange, debridement retention, permanent resection arthroplasty, respectively. duration parenteral 28 days 0‐88 days). Forty-nine (82%) cephalosporin. 5-year estimate free treatment failure 94% (95% confidence interval, 85%‐100%) exchange 71% 44%‐100%) retention. Conclusions. occurs infrequently institution. Prior use is common among associated rate favorable that comparable due known bacterial pathogens. Prosthetic ( PJI) involving athroplasty or can occur up 5% undergoing replacement. Staphylococcus aureus coagulase-negative species account close 65% PJIs [1‐9]. have observed significant number aerobic anaerobic cultures periprosthetic tissue samples did reveal growth any microorganisms. These diagnosis on basis presence purulence, acute pathology revealed by histopathologic examination samples, sinus tract communicating prosthesis. Although microbiologically confirmed