EFFECT OF IPRONIAZID ON SEROTONIN METABOLISM IN VIVO
作者： Donald F. Bogdanski , Sidney Udenfriend , Herbert Weissbach
DOI:
关键词: Biology 、 In vivo 、 Pharmacology 、 Serotonin metabolism 、 Tyramine 、 Iproniazid 、 Endogeny 、 Internal medicine 、 Metabolism 、 Serotonin 、 Monoamine oxidase 、 Endocrinology
摘要: Administration of 1-isopropyl-2-isonicotinyl hydrazide (iproniazid) to animals has been shown produce a 2-to 3-fold increase in endogenous brain serotonin and the amounts appearing following 5HTP. However, iproniazid little effect on peripheral depots or metabolism tyramine when they are administered parenterally. This is due its inability penetrate site monoamine oxidase intact cells.
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