Genome-Scale Modeling of Tissue and Cancer Metabolism
作者： Livnat Jerby , Eytan Ruppin
DOI: 10.1007/978-3-319-01008-3_14
关键词: Genome scale 、 Network analysis 、 Computer science 、 Cancer metabolism 、 Flux (metabolism) 、 Flux balance analysis 、 Constraint (computer-aided design) 、 Constraint based modeling 、 Computational biology
摘要: The emergence of ‘omics’ technologies has enabled global reconstruction cellular metabolic networks. While detailed kinetic modeling these networks remain challenging due to a lack kinetic, network analysis based on appropriate constraints such as the steady-state condition (constraint-based analysis) is already feasible. Here methods for are reviewed along with recent developments in field, including techniques flux balance and elementary modes.
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