Altered Clock and Lipid Metabolism-Related Genes in Atherosclerotic Mice Kept with Abnormal Lighting Condition.

摘要: Background. The risk of atherosclerosis is elevated in abnormal lipid metabolism and circadian rhythm disorder. We investigated whether lighting condition would have influenced the expression clock genes clock-controlled metabolism-related ApoE-KO mice. Methods. A mouse model with disorder was established using mice (ApoE-KO LD/DL mice) by altering exposure to light. C57 BL/6J (C57 exposed normal day night diet served as control According zeitgeber time samples were acquired, test atheromatous plaque formation, serum lipids levels rhythmicity, genes, along Sirtuin 1 (Sirt1) rhythmicity. Results. Atherosclerosis plaques formed aortic arch oscillations altered, diurnal metabolism-associated Sirt1 compared Conclusions. Abnormal light aggravated formation exacerbated disorders levels, oscillation.