Endocrine consequences of long-term intrathecal administration of opioids.
作者： Roger Abs , Johan Verhelst , Jan Maeyaert , Jean-Pierre Van Buyten , Frank Opsomer
关键词: Decreased Libido 、 Hormone 、 Chronic pain 、 Endocrine system 、 Opioid 、 Endocrinology 、 Morphine 、 Free androgen index 、 Anesthesia 、 Cancer pain 、 Internal medicine 、 Medicine
摘要: Intrathecal administration of opioids is a very efficient tool in the long-term control intractable nonmalignant pain. However, despite well known role endocrine regulation, few data are available about possible effects on hypothalamic-pituitary function during this treatment. Seventy-three patients (29 men and 44 women; mean age, 49.2 ± 11.7 yr) receiving intrathecally for pain were enrolled extensive investigation. At time hormonal determination, duration opioid treatment was 26.6 16.3 months; daily dose morphine 4.8 3.2 mg. The group consisted 20 (11 9 54.2 14.0 with comparable syndrome but not treated opioids. Decreased libido or impotency present 23 24 serum testosterone level below nmol/L 25 29 significantly lower than that (P < 0.001). free androgen index was...
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