Progress on Nme (NDP kinase/Nm23/Awd) gene family-related functions derived from animal model systems: studies on development, cardiovascular disease, and cancer metastasis exemplified.
作者： Tien Hsu , , Patricia S. Steeg , Massimo Zollo , Thomas Wieland
DOI: 10.1007/S00210-014-1079-9
关键词: Biochemistry 、 Endocrinology 、 Kinase 、 Enzyme 、 Gene family 、 Metastasis suppressor 、 Nucleoside-diphosphate kinase 、 Internal medicine 、 Gene 、 Nucleotide 、 Biology 、 Nucleoside triphosphate
摘要: The enzyme nucleoside diphosphate kinase (NDP or NDPK) was discovered in the 1950s as biochemical activity that removes terminal phosphate from a triphosphate (NTP) and adds it to (NDP). Thus, correct name for is NTP/NDP transphosphorylase, generally regarded housekeeping required nucleotide homeostasis. At least four of ten Nme gene family products (Nme1– Nme4), also called group I proteins, carry enzymatic activity. A far more complex story started 1990s when became evident enhanced cancer metastasis linked reduced expression named nm23, which turned out be identical humanNme1 = NDPKA. To date, function Nme1 underlying its suppressor has not been clarified. It hoped fundamental cellular molecular insights into role NDP kinase/
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