Regulation of Angiopoietin-Like Proteins (ANGPTLs) 3 and 8 by Insulin
作者： P. A. Nidhina Haridas , Jarkko Soronen , Sanja Sädevirta , Raghavendra Mysore , Fabiana Quagliarini
DOI: 10.1210/JC.2015-1254
关键词: Biology 、 Hyperinsulinemia 、 Betatrophin 、 Insulin 、 Endocrinology 、 Internal medicine 、 Adipose tissue 、 White adipose tissue 、 ANGPTL3 、 Hyperinsulinism 、 In vivo
摘要: Objective: Circulating ANGPTL8 has recently been used as a marker of insulin action. We studied expression and regulation ANGPTL3 in vivo vitro. Design Methods: Expression was 34 paired samples human liver adipose tissue. Effects on 1) plasma concentrations tissue (in 6-h euglycemic hyperinsulinemia; n = 18), 2) gene protein immortalized hepatocytes (IHH) adipocytes were measured. Effect secretion cells stably overexpressing ANGPTL3, -8, or both determined. Results: only expressed the liver, whereas tissues. In hyperinsulinemia significantly decreased at 3 6 hours. Insulin increased 14- 18-fold hours most insulin-responsive tra...
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