Metabolic manifestations of low-dose diuretics

摘要: Hypertension has been defined and treated as a disease of abnormal systolic diastolic blood pressure. Recent data have, however, demonstrated that effective blood-pressure control not resulted in the expected decrease coronary artery disease. These findings are probably result hypertension being complex inherited syndrome cardiovascular risk factors, all which genetically linked contribute to development these patients. Included abnormalities lipid profile, insulin resistance, changes renal function, left ventricular hypertrophy reduced arterial compliance. In many patients, high pressure is late manifestation this process. Since factors heart they should be considered management Diuretics β blockers, when used at doses, negatively impact metabolism sensitivity, while angiotensin converting enzyme (ACE) inhibitors calcium antagonists tend have neutral effect on metabolic factors. decreased use diuretics blockers favor newer agents such ACE antagonists. However, recent low doses (6.25 or 12.5 mg hydrochlorothiazide), lack significant side effects bringing about reductions Thus, hydrochlorothiazide useful drug treatment hypertension, both monotherapy combination therapy.