Toxicogenomics Application to Oncology Drug Development
作者： Luigi Calzolai , Teresa Lettieri
DOI: 10.1007/978-1-60327-088-5_20
关键词: Toxicogenomics 、 Mechanism of action 、 Toxicity 、 Oncology drug 、 Computational biology 、 Drug development 、 Biomarker (cell) 、 Medicine 、 Microarray 、 DNA microarray
摘要: Toxicogenomics tries to evaluate the toxicity and safety of chemical compounds by analyzing gene expression changes detected measuring mRNA levels using DNA microarrays. The measurement upon exposure toxicants can give information about mechanism action toxic compound, also predict unknown compounds, thus providing a valuable tool in investigation lead for drug development. There are few examples its use identify issues drugs that were not evident from preclinical studies.
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Richard O Hynes, Metastatic Potential: Generic Predisposition of the Primary Tumor or Rare, Metastatic Variants—Or Both? Cell. ,vol. 113, pp. 821- 823 ,(2003) , 10.1016/S0092-8674(03)00468-9
Use of a cDNA microarray to analyse gene expression patterns in human cancer. Nature Genetics. ,vol. 14, pp. 457- 460 ,(1996) , 10.1038/NG1296-457
博行 間野, What's going on 造血器腫瘍 Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment. Holleman A, Cheok MH, den Boer ML, Yang W, Veerman AJ, Kazemier KM, Pei D, Cheng C, Pui CH, Relling MV, Janka-Schaub GE, Pieters R, Evans WE. N Engl J Med 2004; 351: 533-42. PMID: 15295046--薬剤耐性急性リンパ性白血病細胞における遺伝子発現パターンと治療反応性 Mebio oncology. ,vol. 2, pp. 69- 71 ,(2005)
Mark Schena, DNA microarrays : a practical approach Oxford University Press. ,(1999)
Steen Knudsen, Guide to analysis of DNA microarray data : Wiley-Liss. ,(2004)
R. A. Lovett, Toxicologists Brace for Genomics Revolution Science. ,vol. 289, pp. 536- 537 ,(2000) , 10.1126/SCIENCE.289.5479.536
Alvis Brazma, Pascal Hingamp, John Quackenbush, Gavin Sherlock, Paul Spellman, Chris Stoeckert, John Aach, Wilhelm Ansorge, Catherine A. Ball, Helen C. Causton, Terry Gaasterland, Patrick Glenisson, Frank C.P. Holstege, Irene F. Kim, Victor Markowitz, John C. Matese, Helen Parkinson, Alan Robinson, Ugis Sarkans, Steffen Schulze-Kremer, Jason Stewart, Ronald Taylor, Jaak Vilo, Martin Vingron, Minimum information about a microarray experiment (MIAME)-toward standards for microarray data. Nature Genetics. ,vol. 29, pp. 365- 371 ,(2001) , 10.1038/NG1201-365
Edward Dere, Darrell R Boverhof, Lyle D Burgoon, Timothy R Zacharewski, In vivo – in vitro toxicogenomic comparison of TCDD-elicited gene expression in Hepa1c1c7 mouse hepatoma cells and C57BL/6 hepatic tissue BMC Genomics. ,vol. 7, pp. 80- 80 ,(2006) , 10.1186/1471-2164-7-80
Ismail Kola, John Landis, Can the pharmaceutical industry reduce attrition rates? Nature Reviews Drug Discovery. ,vol. 3, pp. 711- 716 ,(2004) , 10.1038/NRD1470
M. Schena, D. Shalon, R. W. Davis, P. O. Brown, Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray Science. ,vol. 270, pp. 467- 470 ,(1995) , 10.1126/SCIENCE.270.5235.467