Global changes in and characterization of specific sites of phosphorylation in mouse and human histone H1 Isoforms upon CDK inhibitor treatment using mass spectrometry.
作者： Leesa J. Deterding , Maureen K. Bunger , Geoffrey C. Banks , Kenneth B. Tomer , Trevor K. Archer
DOI: 10.1021/PR700790A
关键词: Gene isoform 、 Cyclin-dependent kinase 、 Kinase 、 Histone 、 CDK inhibitor 、 Histone H1 、 Histone H2A 、 Phosphorylation 、 Chemistry 、 Biochemistry
摘要: Global changes in the phosphorylation state of human H1 isoforms isolated from UL3 cells have been investigated using mass spectrometry. Relative between untreated and treated with dexamethasone or various CDK inhibitors were determined. The specific cyclin-dependent kinase consensus sites on histone that show also investigated. Three H1.4 identified.
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