Effects of in-vivo administration of a monoclonal antibody specific for the interleukin-2 receptor on the acute graft-versus-host reaction in mice

摘要: Parental strain T lymphocyte injected into F1 mice respond to allogeneic MHC antigens and so induce the symptoms of a graft-versus-host reaction (GVHR). We have measured local GVHR by popliteal lymph node assay, showed suppression in treatment with monoclonal antibody (MoAb) AMT-13 which is specific against interleukin 2 (IL-2) receptor on activated mouse lymphocytes. The inhibitory effect administration was comparable L3T4, an MoAb directed helper subset. L3T4 caused dramatic decrease proportion cells phenotype circulation marginal reduction these nodes. In contrast, treated no changes distribution subsets besides those GVHR-stimulated Obviously, only small subset antigen-activated IL-2 receptor-bearing lymphocytes influenced AMT-13. whose expression restricted lymphocytes, such as receptor, might become useful for short term immunosuppression limited side effects.