Characterization of pseudotyped vesicular stomatitis virus bearing the heartland virus envelope glycoprotein.
作者： Miyuki Kimura , Kazutaka Egawa , Tatsuhiko Ozawa , Hiroyuki Kishi , Masayuki Shimojima
DOI: 10.1016/J.VIROL.2020.10.006
关键词: Phlebovirus 、 Glycoprotein 、 Vesicular stomatitis virus 、 Virus 、 Virology 、 Biology 、 Antibody 、 Heartland virus 、 Antigenicity 、 Endocytosis
摘要: The heartland virus (HRTV) is a novel phlebovirus that causes severe infections in the USA and closely related to fever thrombocytopenia syndrome (SFTSV), causative agent for SFTS Asia. entry mechanisms of HRTV remain unclear. Here, we developed pseudotyped vesicular stomatitis bearing glycoprotein (GP) (HRTVpv), antigenicity were analyzed. HRTVpv was neutralized by anti-SFTSV Gc antibody, but not Gn antibodies. Entry cells inhibited bafilomycin A1 dynasore, it enhanced overexpressed with C-type lectins. Production infectious SFTSVpv reduced Nn-DNJ, α-glucosidase inhibitor. occurs via pH- dynamin-dependent endocytosis. Furthermore, Nn-DNJ may be possible therapeutic against SFTSV.
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