Nuclear receptors, bile acids and cholesterol homeostasis series - bile acids and pregnancy.

摘要: Bile acids have been traditionally thought of as having an important role in fat emulsification. It is now emerging that they act signalling molecules not only autoregulate their own synthesis but also influence lipid and glucose metabolism. Although, the mechanisms underlie regulation bile acid homeostasis well characterised normal physiology, impact pregnancy on still poorly understood. This review summarises main regulatory underlying discusses how pregnancy, a unique physiological state, can modify them. The fetoplacental adaptations protect against fetal toxicity are reviewed. We highlight importance during gestation by discussing liver disease intrahepatic cholestasis (ICP) genetic, endocrine environmental factors contribute to aetiology at cellular molecular level.