Overview of orexin/hypocretin system
作者： Michihiro Mieda , Takeshi Sakurai
DOI: 10.1016/B978-0-444-59489-1.00002-1
关键词: Sleep wakefulness 、 Narcolepsy 、 Wakefulness 、 Sleep in non-human animals 、 Sleep disorder 、 Orexin hypocretin 、 Orexin 、 Medicine 、 Energy homeostasis 、 Neuroscience
摘要: A series of recent studies has established the orexin/hypocretin system as a critical regulator sleep/wake states. Its deficiency results in sleep disorder narcolepsy humans, dogs, and rodents. These findings have brought about possibility novel therapies for disorders including insomnia. Moreover, accumulating evidence indicates that regulates wakefulness through interactions with neuronal systems regulate emotion, reward, energy homeostasis. Here, we briefly summarize progress future perspectives.
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