Myoid differentiation and prognosis in adult pleomorphic sarcomas of the extremity: an analysis of 92 cases.

摘要: BACKGROUND The results of a recent study demonstrated an association between myoid differentiation and adverse prognosis in adult patients with pleomorphic sarcoma, as determined by 5-year metastasis-free survival rates. METHODS To confirm the importance muscle on well controlled clinical context, 92 samples from sarcoma extremity single institution were immunostained 4 monoclonal antibodies believed to be correlated differentiation: α-smooth actin, muscle-specific desmin, myoglobin. RESULTS Forty-two cases positive for at least 1 marker 50 uniformly negative. Between two groups, there was no significant difference tumor size, extent, or patient age found; however, histologic grade significantly higher (P = 0.038) tumors. The differed tumors (35%) those without (65%) 0.0054). Myoid remained prognostic indicator after adjusting clinically factors (i.e., grade, age) 0.01) (hazard ratio, 2.39; 95% confidence interval, 1.24–4.63). Furthermore, inverse relation found number markers present 0.004). CONCLUSIONS Myoid independent spindle cell extremity. Cancer 2003;98:805–13. © 2003 American Society. DOI 10.1002/cncr.11617