Simultaneous measurements of pial arteriolar diameter and laser-doppler flow during somatosensory stimulation

摘要: We simultaneously measured pial arteriolar diameter and changes in cortical blood flow during activation of the somatosensory cortex by sciatic nerve stimulation. The vasculature was visualized with a closed-cranial window technique chloralose-anesthetized rats (n = 13). Local monitored laser-Doppler flowmetry. During stimulation (0.2 V, 5 Hz, 20 s), vascular consistently displayed similar response profiles. With 0.5-ms pulses, responses showed an initial peak followed smaller but sustained plateau dilation. In contrast, 5-ms pulses evoked monotonically rising response. Our results support concept that reflect